A 36-year-old woman has died in hospital, two days after a crash south of Batemans Bay.

Emergency crews were called to the Princes Highway on Sunday morning where a Mazda Hatchback and Toyota Land Cruiser towing a caravan had collided.

The female driver and sole occupant of the car was flown to Canberra Hospital with serious head injuries, where she passed away on Tuesday night.

A report will now be prepared for the coroner while police continue to investigate the incident.

Anyone with information or dashcam footage is urged to contact Crime Stoppers on 1800 333 000.