Significant delays are expected along the Tuggeranong Park from Friday night and across the weekend as works are carried out.
From 7pm Friday 14 May, the Parkway will be reduced to one lane in each direction between Heysen Street overpass and the Glenloch Interchange.
The changed conditions will be in place to allow crews to continue their work to upgrade road barriers along the stretch of road.
Due to recent wet weather, the works are due to continue until the end of the month.
The lane closures this weekend are expected to remain in place until 5am Monday 17 May.
Drivers are being advised to avoid the area if they can, Electronic road signage will be in place in to help motorists make early decisions to leave the Parkway and take alternate routes.